Venus Williams of the U.S. returns the ball to Naomi Cavaday of Britain at the Wimbledon tennis championships in London June 24, 2008. (Reuters Photo)

Serving at 40-0 up on her opening service game, the seventh seed was irritated by an insect buzzing around her ankles, and Cavaday raced through the next five points to break and led 3-1 before Williams restored normal service.

"I was about to serve. I felt something on my leg. I looked down. It was a bee, a big old bumblebee," said Williams, who reeled off the last six games to book her place in round two.

"I didn't want it to sting me... then I ended up losing that service game, so I guess the bumble bee got me off to a bad start," she said.

Compatriot Lindsay Davenport, the 25th seed, who returned to the grass court major following a two-year absence, pulled off a 6-3, 5-7 and 6-3 win over Renata Voracova.

Jelena Jankovic, who hopes to join fellow Serbs Ana Ivanovic and Novak Djokovic in the grand slam winner's circle, opened her account with a 6-3, 6-2 win over Ukraine's Olga Savchuk.